Exploring Protease Inhibitors in Placental Development and Maturation

Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation in trophoblasts

M Kandel, L Bartho, NJ Hannan, P Cannon, TV Nguyen, A Nguyen, CN Murphy, GP Wong, S Tong, TJ Kaitu'u-Lino

2026-09-01

Objectives: SIGLEC6, a human-specific transmembrane receptor, is highly expressed in placenta. SIGLEC6 is elevated in maternal cir..

The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts

TJ Kaitu'u-Lino, TM MacDonald, E Keenan, R Hastie, CA Cluver, D Susic, A Henry, JE Myers, LM McCowan, RS Taylor, L Bergman, FZ Marques, DM Kaye, LA Bartho, NJ Hannan, P Cannon, TV Nguyen, M Kandel, C Murphy, GP Wong

2025-08-01

Background: Preeclampsia is a serious complication of pregnancy. Methods: We did an observational study using seven tissue bank/co..

Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia

GP Wong, S Hartmann, O Nonn, P Cannon, TV Nguyen, M Kandel, N de Alwis, CN Murphy, N Pritchard, R Dechend, NJ Hannan, S Tong, DG Simmons, TJ Kaitu’u-Lino

2025-04-01

Leucine-rich repeat-containing G protein-coupled receptors 5/4 (LGR5/LGR4) are critical stem cell markers in epithelial tissues in..

Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction

GP Wong, S Hartmann, DG Simmons, S Ellis, O Nonn, P Cannon, TV Nguyen, A Nguyen, LA Bartho, S Tong, NJ Hannan, TJ Kaitu’u-Lino

2024-10-01

Dysregulated progenitor cell populations may contribute to poor placental development and placental insufficiency pathogenesis. Si..